miRNAs and lncRNAs are non-coding RNA species that act as post-transcriptional regulators of cell proliferation, tissue differentiation, embryonic development, and apoptosis. Specific expression profiles may be characteristic of diseases or disease states and used as biomarkers. The comparison of non-coding RNA patterns in normal and disease samples or within the same sample in the presence or absence of a drug leads to a greater understanding of pathways and mechanisms of action. The identification of miRNA and lncRNA profiles has become important for streamlining drug development processes.
The WaferGen SmartChip System in conjunction with the pre-validated SmartChip human miRNA panel, offers researchers the ability to carry out comprehensive, rapid miRNA profiling on their human samples simply, cost-effectively, and accurately.